A biological and chemical technology company had engineered an organism useful for generating a fermentation product of interest. Assistance was requested from MATRIC on isolating and purifying the product, which was obtained in a dilute aqueous broth. The first activity undertaken was to develop a preliminary process design, including an analysis of the very approximate OPEX and CAPEX as guidance in considering various process options. This allowed a comparison of the potential approaches for product concentration and purification. Next, samples of broth were delivered to MATRIC for evaluation of selected approaches. The results provided the company a perspective on the routes with most promise for further development.
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